David E Briles Selected Research

pneumococcal surface protein A

10/2015	Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection.
9/2014	Preparation and testing of a Vi conjugate vaccine using pneumococcal surface protein A (PspA) from Streptococcus pneumoniae as the carrier protein.
7/2014	Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC.
12/2013	A modified surface killing assay (MSKA) as a functional in vitro assay for identifying protective antibodies against pneumococcal surface protein A (PspA).
10/2012	The absence of PspA or presence of antibody to PspA facilitates the complement-dependent phagocytosis of pneumococci in vitro.
2/2011	A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice.
1/2011	Maternal immunization with pneumococcal surface protein A protects against pneumococcal infections among derived offspring.
1/2011	Protection of pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A.
7/2009	Virulence of pneumococcal proteins on the inner ear.
10/2008	Distribution of pneumococcal surface protein A families 1 and 2 among Streptococcus pneumoniae isolates from children in finland who had acute otitis media or were nasopharyngeal carriers.

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David E Briles Research Topics

Disease

38	Pneumococcal Infections 01/2021 - 04/2002
33	Infections 01/2022 - 01/2003
13	Pneumonia (Pneumonitis) 01/2021 - 05/2002
11	Otitis Media 10/2017 - 02/2004
9	Sepsis (Septicemia) 01/2020 - 08/2003
6	Pneumococcal Pneumonia 01/2022 - 08/2003
4	Bacterial Infections (Bacterial Infection) 10/2017 - 09/2007
4	Inflammation (Inflammations) 09/2016 - 01/2008
3	Bacteremia 01/2020 - 01/2003
3	Respiratory Tract Infections (Respiratory Tract Infection) 05/2013 - 04/2003
2	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 01/2020 - 01/2016
2	Meningitis 12/2015 - 10/2015
2	Otitis Media with Effusion 09/2013 - 11/2010
1	Coinfection 01/2021
1	Lung Diseases (Lung Disease) 10/2018
1	Autolysis 12/2017
1	Atherosclerosis 06/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 06/2017
1	Typhoid Fever (Typhoid) 09/2014
1	Communicable Diseases (Infectious Diseases) 01/2013
1	Fibrosis (Cirrhosis) 09/2012
1	Non-alcoholic Fatty Liver Disease 09/2012
1	Disease Progression 06/2012
1	Necrosis 06/2012
1	Sensorineural Hearing Loss 12/2008
1	Hearing Loss (Hearing Impairment) 12/2008

Drug/Important Bio-Agent (IBA)

20	VaccinesIBA 01/2021 - 04/2003
16	pneumococcal surface protein AIBA 10/2015 - 03/2003
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
9	Polysaccharides (Glycans)IBA 01/2022 - 02/2004
9	Conjugate VaccinesIBA 01/2020 - 08/2003
8	AntibodiesIBA 06/2017 - 08/2003
7	AntigensIBA 06/2017 - 04/2003
6	Membrane Proteins (Integral Membrane Proteins)IBA 07/2014 - 05/2002
5	Streptococcus pneumoniae plY proteinIBA 01/2021 - 08/2003
4	CytokinesIBA 12/2015 - 09/2007
3	flt3 ligand protein (flt3 ligand)IBA 06/2017 - 09/2007
3	Carrier Proteins (Binding Protein)IBA 10/2015 - 04/2009
2	Combined VaccinesIBA 01/2022 - 09/2014
2	4-nitrophenethyl bromide (NPB)IBA 01/2021 - 05/2010
2	Capsules (Microcapsules)IBA 10/2018 - 02/2010
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2017 - 09/2007
2	Virulence Factors (Pathogenicity Factors)IBA 09/2016 - 07/2009
2	Attenuated VaccinesIBA 01/2013 - 03/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2012 - 09/2007
2	LactoferrinIBA 02/2010 - 01/2003
2	CC ChemokinesIBA 04/2009 - 05/2007
2	LigandsIBA 04/2009 - 05/2007
2	EnzymesIBA 10/2008 - 11/2007
2	ZincIBA 01/2008 - 04/2003
2	Complement System Proteins (Complement)IBA 12/2007 - 01/2003
2	Immunoglobulin G (IgG)IBA 11/2007 - 12/2002
2	Complement Receptors (Complement Receptor)IBA 12/2004 - 12/2002
1	Lactate Dehydrogenase 5IBA 01/2021
1	Amino Acids FDA Link 01/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2021
1	SmokeIBA 11/2018
1	Immune Sera (Antisera)IBA 01/2018
1	small cardioactive peptide BIBA 01/2018
1	Lipase (Acid Lipase)FDA Link 12/2017
1	FibrinIBA 10/2017
1	Complementary DNA (cDNA)IBA 06/2017
1	OligodeoxyribonucleotidesIBA 06/2017
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2016
1	aluminum sulfate (alum)IBA 10/2015
1	Choline (Choline Chloride)IBA 10/2015
1	Ethanol (Ethyl Alcohol)IBA 01/2015
1	Peroxidase (Myeloperoxidase)IBA 01/2015
1	polyethylene glycol polyethyleneimine nanogelIBA 05/2013
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2012
1	Scavenger Receptors (Scavenger Receptor)IBA 09/2012
1	oxidized low density lipoproteinIBA 09/2012
1	Interleukin-6 (Interleukin 6)IBA 09/2012
1	Immunoglobulin M (IgM)IBA 09/2012
1	LipidsIBA 09/2012
1	CholesterolIBA 06/2012
1	Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA 03/2012
1	Neuraminidase (Sialidase)IBA 06/2011
1	Penicillins (Penicillin)FDA Link 06/2011
1	Tumor Viral Antigens (Large T Antigen)IBA 06/2011
1	Thomsen-Friedenreich antigenIBA 06/2011
1	CPG-oligonucleotideIBA 02/2011
1	Secretory Immunoglobulin A (SIgA)IBA 02/2011
1	apolactoferrinIBA 11/2010
1	SB 225002IBA 06/2010
1	Interleukin-8B ReceptorsIBA 06/2010
1	Monoclonal AntibodiesIBA 05/2010
1	Proline (L-Proline)FDA Link 05/2010
1	EpitopesIBA 05/2010
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2010
1	Daptomycin FDA Link 02/2010
1	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 02/2010
1	LipopeptidesIBA 02/2010
1	Surface Antigens (Surface Antigen)IBA 07/2009
1	Chemotactic FactorsIBA 04/2009
1	PolyaminesIBA 04/2009
1	Immunoglobulin A (IgA)IBA 11/2007
1	NF-kappa B (NF-kB)IBA 08/2007

Therapy/Procedure

1	Ambulatory Care (Outpatient Care) 09/2014